Among the latter, NPY- and PV-IR neurons, in particular, can be selectively affected in many pathologic conditions, including Angelman syndrome (Godavarthi et al., 2014), Alzheimer’s disease (Ramos et al., 2006), schizophrenia (Stansfield et al., 2015), aging (Pugliese et al., 2004; Kuruba et al., 2011), and seizures (Sun et al., 2007). This evidence concerns the gene NPY and early-onset autosomal dominant Alzheimer disease.