In particular, Wong and colleagues have previously shown that the miR-212/132 cluster is down-regulated in temporal cortex in AD, and that inhibition of miR-212 and/or miR-132 expression can induce apoptosis in primary neurons after 1 week in culture via activation of a foxo3a-mediated cell death pathway (Wong et al., 2013). The gene discussed is FOXO3; the disease is Alzheimer disease.