Interestingly, many of these proteins are associated with known pathophysiological features of DMD including muscle function (MB, TNNI2, TNNI3), metabolic dysregulation (PGAM1, LDHB, TPI1, FABP3), calcium metabolism (CAMK2A, CAMK2B, CAMK2C, CAPN1), and extracellular matrix remodelling/fibrogenesis (ADAMTS5, THBS4)24. The gene discussed is THBS4; the disease is Duchenne muscular dystrophy.