PDLIM7 and nasopharyngeal carcinoma: Our finding of 2 nucleotide variations(A-39C and G-44C, the latter is also observed in essentially all NPC-EBVs), albeit different, located within and potentially disrupting the LRS CRE of the LMP-1 promoter (Fig. 3B) in the 11 similar BL EBVs is consistent with the hypothesis that substitutions in regulatory sites may be a feature of carcinogenic EBV variants.