Yan and co-workers [287] also found that the mutant KRAS expressing hepatocytes expressed increased amounts of TGFB1 (TGFB1a), and that blocking of TGF-β pathways reduced both the number of neutrophils and carcinoma growth, and changed the cytokine gene expression pattern of the tumor-associated neutrophils. The gene discussed is TGFB1; the disease is carcinoma.