In aggregate, the functional connections of Wnt activation with increases in tumor generation, metastasis, self-renewal, standard PCSC markers (CD133, CD44, and ABCG2), and pluripotency genes (OCT4 and NANOG) strongly support an important role of the Wnt/β-catenin signaling in promoting PCSLCs. The gene discussed is ABCG2; the disease is neoplasm.