This is important as it leads to the conclusion that ROS-induced genomic instability in CML cells begins in LSCs and progresses in LPCs, which was supported by the observation that mutations in the BCR-ABL1 gene associated with TKI resistance were observed in CP CML in the CD34+ CD38− (stem) and CD34+ CD38+ (progenitor) cells [69]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.