The results obtained for NHEJ functioning in BCR-ABL1-positive cells should be also viewed in a broader context as it was reported that Ku86 suppressed chromosomal aberration and cancer transformation in mice as Ku86 double mutants showed chromosomal instability and significantly higher frequency of B-cell lymphoma [93]. The gene discussed is XRCC5; the disease is B-cell non-Hodgkin lymphoma.