This is consistent with previous animal research [21,23] and the human study of O’Donnell et al. (2012) [32], where maternal anxiety was measured one day before term and exhibited a significant positive association with the downregulation of HSD11B2. These findings are also noteworthy because maternal cortisol levels are usually at their peak during the third trimester of pregnancy [42]. This evidence concerns the gene HSD11B2 and Anxiety.