HSD11B2 and Anxiety: Pearson correlations also revealed a negative relationship between depressive symptoms (as measured by the EPDS) and HSD11B2. Similar to anxiety, the effect was greater in the third trimester than the first, with 7% of the variation in HSD11B2 being explained by Trimester 3 EPDS scores (in comparison to 1.25% during the first trimester).