An ANCOVA controlling for BMI, smoking and alcohol consumption revealed that group status (antidepressant exposure, untreated depression and controls) accounted for 5.9% of HSD11B2 expression (F (2, 32) = 0.84, p = 0.44, n = 33) instead of 7.1% (the computed effect size without consideration of covariates). This evidence concerns the gene HSD11B2 and depressive disorder.