FIS1 and myocardial infarction: Decreasing mitochondrial fission with Mdivi-1 (which inhibits the activity of the outer mitochondrial membrane fission protein Drp1) or P110 (which disrupts the interaction between Drp1 and the mitochondrial-docking protein Fis1) is protective, reducing the severity of myocardial infarction caused by ischemic reperfusion46, 47.