Anti‐IgE appears to be is a very promising therapy for IgE‐mediated allergic diseases, and probably acts by two mechanisms: preventing free IgE molecule from binding to its receptors on effector cells, and through effects on effector cells including by downregulating the expression of the high‐affinity IgE receptor on mast cells, and decreasing basophil histamine release 82. The gene discussed is IGHE; the disease is allergic disease.