For instance, specific transcriptional signatures enriched for genes involved in memory T-cell generation and receptor-signaling (including IL-7) have been described in UC and Crohn's disease that accurately predict colectomy risk from the point of diagnosis; it is plausible that such bioindicators also exist in immune-mediated liver diseases given the overlapping defects in mucosal immunogenicity.91 Here, IL7 is linked to Crohn disease.