NFKB1 and acute lymphoblastic leukemia: In T-ALL cell lines (MOLT-4 and JURKAT) we observed a reduction of Ser536 phosphorylation after the combined treatment, with respect to single agents, while in B-ALL cell lines (KOPN-8 and RS4;11), Ser536 p-NF-κB was markedly induced by the bortezomib/CX-4945 combination (Figure 4B).