The mechanistic cytotoxic activity of garcinol similar to isogarcinol which may include downregulation of MMP-9, IL-8, PGE-2, and VEGF, markers of angiogenesis and metastasis in pancreatic cancer cell lines, Panc 1 and BxPC3 and induction of ROS through death receptor, mitochondrial and modulating GADD153 [34, 35]. The gene discussed is VEGFA; the disease is familial pancreatic carcinoma.