For position 12 specifically, lung squamous cell carcinoma (LUSC) has six mutations (LUSC, Figure 2B) while lung adenocarcinoma (LUAD) has three with the majority of these position 12 mutations being in KEAP1. Accordingly, KEAP1 has previously been reported as significantly altered in large-scale sequencing projects in lung adenocarcinoma (19) and lung squamous cell carcinoma (20). This evidence concerns the gene KEAP1 and lung adenocarcinoma.