SOX2 and neoplasm: For example, HOTAIR lncRNA regulates tumor invasion and metastasis [85], SOX2-overlapping transcript (SOX2-OT) and focally amplified long noncoding RNA in epithelial cancer (FALEC or FAL1) lncRNAs are involved in maintaining cancer cell stemness [86, 87], and imprinted maternally expressed transcript (H19), steroid receptor RNA activator (SRA) and growth arrest-specific 5 (GAS5) regulate cell proliferation and apoptosis [88–90].