Compared to SNS-gp130flox/flox mice SNS-gp130−/− mice showed significantly weaker initial swelling, reduced serum concentrations of CGRP, IL-6, and IL-2, no inflammation-evoked upregulation of CGRP in sensory neurons, but similar histopathological arthritis scores during AIA. The gene discussed is IL2; the disease is arthritic joint disease.