OIP5 and clear cell renal carcinoma: From the analysis made to discern novel candidate associated genes with gene sets, we observed that a target gene of interest, OIP5, already associated with centromeres in the G1 phase of cell cycle [43] and with different types of tumors, such as gastric, testis [44] and clear cell renal cell carcinoma [45], was also strongly associated with pathways involved in transcription and RNA degradation (Additional file 6: Sheets 3 and 4).