This tendency totally reverted through the infection course and by day 7 pi the activation of a massive number of immune mediators was observed as demonstrated in here with the significant up-regulation of: IL-5, DEFB2, TLR-3, IL-6, IL-8, IL-1β, IL-21, IL-23 and IL-10; coinciding with the cytokine storm described during the terminal phase of acute ASF [36] (Figure 6B). Here, IL21 is linked to infection.