CD163 and Sepsis: Besides these two cytokines, several other soluble factors were found at high levels in sera from severely ASF-affected pigs by day 7 pi with E75, including IL-12 and IL-1β (data not shown) and for the first time, also for sCD163 (Figure 8C), an activation macrophage marker that has been associated with several chronic inflammatory diseases, sepsis, and more recently also with certain haemorrhagic fever diseases caused by viruses [38].