By day 31 pi, once the E75CV1 infection has been resolved and the memory specific B and T-cell responses have been established, a very tight regulation of the immune response was observed with only 2 genes being significantly up-regulated: IL-23 and NFκB; and another two significantly down-regulated: IL-1β and IL-4, signature of Th 17-like responses. Here, IL4 is linked to infection.