IL21 and infection: Conversely to what has been shown for E75CV1 the progression of the E75-infection resulted in a dramatic imbalance of the immune system by day 7 pi, with the significant up-regulation of 9 genes, namely: IL-5, IL-1β, IL-6, IL-8, IL-10,IL-21, IL-23, DEFB2 and TLR-3.