IL21 and infection: Confirming the inverse tendency described for E75, a more equilibrated immunological balance was observed with the progression of the E75CV1-infection, with 6 genes showing significant transcription up-regulation at day 7 pi: IFN-γ, IL-5, TNF-α, TGF-βR1, IL-21, IL-23 and 4 extra genes showing a significant down-regulation: DEFB1, CD163, IL-13 and IL-18 (Figure 6B).