A careful dissection of the transcription profile by day 1 pi in tissues from E75CV1-infected pigs, allowed the confirmation of the significant up-regulation of CD163, IL-1β, IFN-γ, IL-5, IL-6, IL-10, IL-12p40, TNF-α and TGF-βR1 and the down-regulation of DEFB2, immediately after E75CV1 infection. Here, TNF is linked to infection.