However, given that the off-target toxicity of MAGE-A3-specific aTCR for myeloma and melanoma in a clinical trial caused the death of some patients [111], a clinical trial of HIV-1-infected patients, NCT00991224, was suspended before any participant was infused with A2-SL9-specific aTCR-transduced CD8+ T cells [112]. This evidence concerns the gene CD8A and melanoma.