Thus, in ischemia/reperfusion injury, we hypothesize that the production of ac-PGP in brain may promote inflammation and neurodegeneration through upregulation of CXCR1/2 receptors, increased permeability of the blood-brain barrier, recruitment and activation of leukocytes, and direct neuronal injury mediated through prolonged CXCR2 receptor activation. Here, CXCR1 is linked to ischemia.