The CXCR2 chemokine receptor is the primary receptor mediating neutrophil chemotaxis, and CXCR2 and its ligands, CXCL1 (growth-related oncogene α (GRO-α)), CXCL2 (growth-related oncogene β (GRO-β)), and CXCL8 (interleukin-8 (IL-8)) are implicated in injury processes in stroke and other neurological disorders. Here, CXCR2 is linked to stroke disorder.