AGO1 and hepatocellular carcinoma: On the contrary, low AGO1 expression in combination with high let-7 and high VEGF profile are a set of markers observed in the hypoxic core regions of mouse tumor xenografts; in addition, statistical analysis has revealed that HCC (human hepatocellular carcinoma) patients with low AGO1 and high VEGF levels are correlated with poor cancer survival [21].