SOX2is regulated by HH signaling where transcriptionfactorsGLI1 and GLI2 directly bind to the proximal promoter region of SOX2 in primary melanoma cells[48].Also, human SOX14 expression is GLI1 dependent in U87MG cells and SHH dependent in U87MG and HepG2 cells[49]. The gene discussed is GLI2; the disease is melanoma.