Furthermore, the antioxidant effects of ployphenolic compounds (-)-epigallocatechin-3-gallate (EGCG) and resveratrol are activated by Sirt1 [35, 36], and a previous study involving an AD mouse model showed that Sirt1 suppresses the production of Aβ by activating α-secretase [37–39]. Here, SIRT1 is linked to Alzheimer disease.