We next examined the effects of inhibiting NF-κB on Imatinib sensitivity in GIST882 cells, and found the addition of Bay11–7082 could potentiate the Imatinib inhibitory effects on proliferation in GIST882 cells with or without the over-expression of p55PIK, indicating that the inhibition of NF-κB restored the sensitivity of IMA-resistance-GIST cells to Imatinib (Figure 2E). The gene discussed is PIK3R3; the disease is gastrointestinal stromal tumor.