In addition to observing that co-culture CM could stimulate the transactivation of ERβ, results from western blot analysis indicated that co-culturing RCC cells and T cells could increase ERβ protein expression in 786-O and A498 cells (Fig. 3B), suggesting that recruited T cells may promote RCC cell invasion via increasing the activity and expression level of ERβ. Here, ESR2 is linked to renal cell carcinoma.