In addition to IFN-γ, we found that the co-culture of T cells with RCC cells could increase the expression of IGF-1 and FGF7 in T cells (Fig. 5B), and knocking down ERβ in 786-O cells could reverse the T cells/RCC cells co-culture-enhanced IGF-1 and FGF-7 production from T cells (Fig. 5C). The gene discussed is IGF1; the disease is renal cell carcinoma.