To further investigate the functions and the correlation of DAB2IP in ERβ-promoted RCC invasion, we knocked down DAB2IP in 786-O cells that have been transduced with lentiviral shERβ and the results showed that knockdown of DAB2IP can reverse shERβ-reduced 786-O invasion (Fig. 4D). This evidence concerns the gene ESR2 and renal cell carcinoma.