CD44 and neoplasm: MCT1 expression at the plasma membrane suggests a high lactate efflux from cancer cells, which, besides allowing glycolytic flux for energy production, also detains an important role in the microenvironment, by decreasing the immune response against tumor cells [30], increasing tumor cell motility [31], inducing angiogenesis [32], as well as stimulating hyaluronan and its receptor CD44, molecules involved in the process of cancer invasion and metastasis [33].