Given the importance of these neoplasms, particularly in the Brazilian environment [26, 27], and the potential use of molecular players of aerobic glycolysis as prognostic tools and therapeutic targets [10, 12, 28], the aim of the present work is to study the pattern of expression of the metabolism-related proteins MCT1, MCT2, MCT4, their chaperones CD147 and CD44, as well as GLUT1 and CAIX in adult ACC, and to determine whether these proteins have some biological and/or prognostic predictive value. Here, CD44 is linked to adrenal cortex carcinoma.