HHEX and type 2 diabetes mellitus: Genome wide association studies (GWAS) showed that many genes including Calpain 10 and TCF7L2 (transcription factor 7-like 2) are associated with T2DM. HHEX (hematopoietically expressed homeobox), SLC30A8 (solute carrier family 30 (zinc transporter), member 8), CDK2A/B (cyclin-dependent kinase inhibitor 2A/B), and IG2BP2 (insulin-like growth factor 2) are other genes which have been shown to be associated with T2DM based on GWAS.