The following genes showed significant association with T2DM: haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, resistin, INSR, ACE, ApoA-I, adiponectin, and PTPN1. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.