Other variants which had significant association with T2DM included haptoglobin (allele 2-2), leptin (G-2548A polymorphism), paraoxonase 2 (Ser311Cys polymorphism), GST (glutathione-S-transferase) M1 and GSTM1/GSTT1 interaction, calpain-10 (SNP (single nucleotide polymorphism) 43), IRS-1 (G972R polymorphism) and IRS-2 (G1057D polymorphism), VDR (vitamin D receptor) (TaqI polymorphism), KCNJ11 (E23K polymorphism), eNOS (endothelial nitric oxide synthase) VNTR (intron 4 a/b polymorphism), resistin (−420C/G polymorphism), and ACE (Insertion/Deletion) [35–37, 45, 47, 50, 55, 57, 58, 64, 70]. The gene discussed is NOS3; the disease is type 2 diabetes mellitus.