Association of some other genes including osteopontin (rs1126772 polymorphism), integrin α4 (rs1449263 polymorphism), CD44 (rs8193 polymorphism), and TGFβ (transforming growth factor) (+915C/G polymorphism) was also investigated in 2 studies and no significant relation was observed between these variants and T1DM [23, 29]. The gene discussed is SPP1; the disease is type 1 diabetes mellitus.