MTOR and malaria: On the other hand, in vitro studies using the BeWo cell line exposed to malaria-associated cytokines plus chemokines (secreted by human monocytic cell line (THP1) cells that were incubated with P. falciparum infected red blood cells) induced dysregulation of mTOR pathway [61], suggesting that mTOR pathway in ST might be interfered by placental malaria-inflammatory-cytokines.