Systemic changes that occur in uremic patients such as the significant increase in advanced glycation end products (AGEs), nitric oxide synthase (NOS), Tumor Necrosis Factor Alpha (TNFα), and Vascular Endothelial Growth Factor (VEGF) levels, but also hyperosmolarity and blood pressure itself, may influence peritoneal permeability and cause thickening of the extracellular matrix and mild vasculopathy [9, 10]. The gene discussed is VEGFA; the disease is vascular disorder.