The reproductive tract, respiratory tissues, and salivary glands are the main sources expressing HE4, it also is remarkably increased by ovarian cancer cells, and it is considered one of the main tumor markers, especially in specific types of ovarian cancer including serous or endometrial carcinoma (Galgano, Hampton & Frierson, 2006; Nagy et al., 2012). The gene discussed is WFDC2; the disease is endometrial carcinoma.