Thus, we showed that even few glucose samples, not requiring specific medical instrumentation (such as devices for continuous glucose monitoring), or additional self-monitoring glycemic readings (compared to those typically performed in insulin treated patients with type 2 diabetes), are sufficient to provide relevant information on glycemic control and variability: in fact, improvements in glycemic control and variability due to vildagliptin can be observed even when postprandial excursions are not determined. This evidence concerns the gene INS and type 2 diabetes mellitus.