CYP1B1 and neoplasm: We selected these genes because all six were present in the angiogenesis signature unique to PDAC (Table 1), because CYP1B1 was the most significantly and highly up-regulated, and because ANGPT1, its receptors TIE1 and TEK, and HIF1A are commonly associated with pathways that enhance tumor angiogenesis [20, 21].