MAP is suspected in an individual who has: colonic adenoma count between one and ten before the age of 40; colonic adenoma and/or hyperplastic polyp count between ten and a few hundred; colonic polyposis (i.e., >100 colonic polyps) in the absence of a germline APC mutation; CRC with the somatic KRAS mutation c.34G > T in codon 12; and, family history of CRC (with or without polyps) consistent with autosomal recessive inheritance [27]. Here, APC is linked to colon adenoma.