In patients with oral squamous cancer (Tamaki et al. 2009) and in patients with hepatocellular carcinoma (Jiang et al. 2011), the A5.1 genotype was associated with higher sMICA serum levels, and Raji cells constructed to express the MICA A5.1 allele produced more sMICA than cells transfected to express a full-length MICA A5 allele (Lü et al. 2009). The gene discussed is MICA; the disease is hepatocellular carcinoma.