In patients with ulcerative colitis, the MICA-129Val/Val genotype was associated with higher sMICA serum levels (Zhao et al. 2011) and the MICA-129Met allele was associated with lower sMICA serum levels in hepatitis B virus-induced hepatocellular carcinoma patients and healthy controls (Tong et al. 2013). The gene discussed is MICA; the disease is ulcerative colitis.