We found that infection with PKD1 shRNA (Open Biosystems/Thermo Fisher Scientific, Lafayette, CO; Additional file 7: Figure S7A) selectively reduced the expression of endogenous PKD1 without affecting the expression of other proteins such as PKC-α (Additional file 7: Figure S7B) when compared with those following infection with control shRNA (Additional file 7: Figure S7B). The gene discussed is PRKCA; the disease is infection.