Of note, TCF7L2 is an upstream regulator of the mouse Slc30a8 (44) and human SLC30A (45) genes and, as a “master” regulator of T2D susceptibility (45), might act in part via ZnT8 to modify β-cell Zn2+ release and insulin clearance. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.