Murine sFasL is reported to be non-apoptotic and anti-inflammatory, and can even act as an antagonist by blocking mFasL engagement with the Fas receptor.17, 18 We previously demonstrated the neuroprotective effects of sFasL in a TNFα-triggered model of retinal ganglion cell neurotoxicity.22 In the current study, we simultaneously injected recombinant sFasL into the subretinal space when the retinal detachment was created, which attenuated the subsequent photoreceptor cell death. The gene discussed is FASLG; the disease is retinal detachment.