The function of Fas/FasL in photoreceptor death was examined by our group in a rat model of retinal detachment,5 as well as other groups who observed a significant decrease in photoreceptor apoptosis in FasLgld and Faslpr mutant mice.6, 20 However, although these data demonstrate clearly that this pathway contributes to photoreceptor cell loss in detached retinas, these studies did not examine the contribution of the different forms of FasL (mFasL and sFasL). The gene discussed is FASLG; the disease is retinal detachment.