CCL2 and retinal detachment: We previously demonstrated that monocyte chemoattractant protein 1 (MCP-1) is an essential mediator of early infiltration of macrophage/microglia after retinal detachment.24 Zacks et al.25, 26 observed that interleukin 6 (IL-6) was also increased in the retina after retinal detachment using gene microarray analysis.