There have been several previous reports examining the function of Fas signaling in photoreceptor cell death after retinal detachment using Fas or FasL mutant mice.6, 20 Hisatomi et al.20 reported that neither Fas deficiency (lpr/lpr) nor FasL deficiency (gld/gld) offered protection against photoreceptor cell death after retinal detachment. Here, FAS is linked to retinal detachment.