Nrf2 contributes to cancer development by targeting not only the typical cytoprotective genes but also genes involved in cell metabolism including G6PD.15 To test a potential role of Nrf2 in HBV-triggered upregulation of G6PD, we performed Nrf2 RNA interference and checked G6PD expression and activity in Huh7 cells. This evidence concerns the gene NFE2L2 and cancer.