Necroptosis may be associated with the cisplatin toxicity-associated cell death56 and Necrostatin-1 has been shown to confer protection in cisplatin-treated human proximal tubular cells.57 In the mouse model of cisplatin-induced AKI, the deterioration of renal morphology was attenuated by Necrostatin-1.20 However, there are possible explanations, which include non-necroptotic functions of RIPK3 and off-target effects of Necrostatin-1 that might explain these findings which are not ruled out in detail. The gene discussed is RIPK3; the disease is acute kidney injury.