Necroptosis was shown to be present in remote hepatic injury associated with ischemic acute kidney injury (AKI).76 TNFR and RIPK3 showed significantly high expression levels in immunoblot analyses, and positive hepatocytes of RIPK3 immunohistochemical staining were also evident in livers of rats with ischemic AKI. Here, RIPK3 is linked to acute kidney injury.