Specifically, Huan et al. showed the presence of transcripts with prognostic relevance in AML, human CXCR4 and IGF-IR (insulin-like growth factor-I receptor) mRNA, in murine BM stromal cells, thus demonstrating that AML exosomes transfer leukemia-derived mRNAs to BM stromal cells. The gene discussed is IGF1R; the disease is leukemia.