Taverna et al. showed that exosomes released from CML cells directly affect ECs by modulating the process of neovascularization, both in vitro and in vivo, by inducing in ECs the release of proangiogenic cytokines, such as Interleukin-8 [52]. This evidence concerns the gene CXCL8 and chronic myelogenous leukemia, BCR-ABL1 positive.