CXCL8 and chronic myelogenous leukemia, BCR-ABL1 positive: The inhibition of IL8 receptors, using SB225002, was able to abrogate the IL8- driven CML cell survival in vitro as well as the growth of CML xenograft in vivo, thus indicating a key role of CXCLl8/CXCR1-2 signaling in the growth of CML cells [36].