IL17A and experimental autoimmune encephalomyelitis: In addition, using IL-17+ cell fate mapping reporter mice, Hirota et al. demonstrated that IFN-γ producing CD4+ T cells in spinal cords of experimental autoimmune encephalomyelitis (EAE) mice (a mouse model for multiple sclerosis) almost all derived from ex-Th17 cells, although they have stopped producing IL-17 [27].