When transferred into tumor bearing mice (Malignant Pleural Mesothelioma (MPM)), tumor Ag specific ICOS based CAR Th17 cells induced strong tumor rejection, demonstrating that ICOS based CARS, that consequently promote Th17/Th1 plasticity, might be a promising approach in tumor immunotherapies [111]. This evidence concerns the gene RENBP and malignant pleural mesothelioma.