In addition, Th17 cell transfer has shown incredible efficiency to treat established tumors in mouse models, and translation into humans therefore represents promising although challenging future cellular therapies. In vitro, polarized Th17 cells transferred into mice are long-lived and self-renewing gave rise to Th1-like effector T cells, while persisting as IL-17 producing cells and controlled tumor growth [98]. Here, IL17A is linked to neoplasm.