SERPINA1 and autoimmune type 1 diabetes: Clinical studies that examine the prospect of AAT therapy for individuals who are not genetically deficient in AAT incorporate major findings recently established with regard to AAT and T cells, namely, recent onset type 1 autoimmune diabetes (NIH clinical trial registries NCT01183455, NCT01319331, NCT01183468, NCT02005848, NCT01304537, and NCT01661192) and treatment-resistant GvHD (NCT01523821).