EVs can be implicated in neurodegenerative diseases also because they can deliver toxic proteins such as prions (PrPsc) [123–125], alpha-synuclein [126, 127], amyloid precursor protein (APP) or β-amyloid peptides [128–133], phosphorylated Tau [134], and SOD1 [135]. This evidence concerns the gene APP and neurodegenerative disease.