As VEGF contributes to cardiomyocyte function and growth on the one hand and to the integrity and expansion of the coronary and systemic circulation on the other one [8, 10, 11, 45, 67–70], it is not surprising that VEGF antagonism may lead to cardiovascular side effects, principally hypertension, thromboembolism, LV dysfunction, and HF [71–73]. The gene discussed is VEGFA; the disease is hypertensive disorder.