PRMT1 is thought to be involved in diabetic retinopathy, as PRMT1 expression is increased via the generation of reactive oxygen species (ROS) in the retinas of streptozotocin-treated rats and high-glucose-treated bovine retinal capillary endothelial cells, which are a crucial component of the inner BRB [5]. The gene discussed is PRMT1; the disease is diabetic retinopathy.