CYP2C8 and cholestasis: Liver donors diagnosed with cholestasis (Nies et al., 2009) had lower CYP2C8 protein levels (median difference, –26.8 pmol/mg [95% CI, 6.1–47.8]; donors with abnormal bilirubin serum levels had lower levels of protein (–36.47 pmol/mg [95% CI, 17.21–58.56]) and enzyme activity (–351.8 pmol/mg/min [95% CI, 125.95–562.92]); and donors with elevated serum gamma glutamyl transferase also had decreased protein levels (–17.52 pmol/mg [95% CI, 0.83–35.62]).