However, all the associations between the ratios of TG/HDL-C, TC/HDL-C and LDL-C/HDL-C and the severity of CHD became insignificant after adjusting for the variables in model 1 plus the individual lipid variables including TG, HDL-C, LDL-C, apoB100 and apoAI. The gene discussed is APOA1; the disease is coronary artery disorder.