APOE and Alzheimer disease: Moreover, ApoE4 and gender have prominent interaction, with the ApoE4 link to AD far more pronounced in women than in men (Corder et al., 2004; Fleisher et al., 2005; Lehmann et al., 2006; Damoiseaux et al., 2012; Altmann et al., 2014; Ungar et al., 2014).