The network topology analysis performed in this study revealed a set of central nodes associated to glioma malignancy, such as Map3k14, Mapk1, Actn4, Hspa5, Atf2, Rac1,E2f1, Shc1, Pik3ca, Akt1, Vim and Egr1. This evidence concerns the gene ATF2 and central nervous system cancer.