The network topology analysis performed in this study revealed a set of central nodes associated to glioma malignancy, such as Map3k14, Mapk1, Actn4, Hspa5, Atf2, Rac1,E2f1, Shc1, Pik3ca, Akt1, Vim and Egr1. This evidence concerns the gene ACTN4 and glioma.