GPNMB and obesity due to melanocortin 4 receptor deficiency: Here, we generated aP2 promoter-driven Gpnmb transgenic (Tg) and deficient mice carrying C-terminal-truncated form of Gpnmb with 150 amino acids, and they were subjected to the diet-induced obesity model, since we found Gpnmb is highly expressed in white adipose tissues (WATs) in obesity and it has also been reported to be induced in obese adipose tissue macrophages, recently31.