Although the expression of Gpnmb is regulated by BMP-2 in osteoblasts, RANKL (receptor-activated NFκB ligand) in osteoclasts, CSF (colony stimulating factor) in hepatocellular carcinoma, endothelin-1 in melanoma cells and mTORC1 in adipocytes, the expression regulation of Gpnmb in hepatic macrophages and stellate cells under obesity is not elucidated in current investigation. Here, CSF2 is linked to obesity due to melanocortin 4 receptor deficiency.